수산대사체학
- 연구실소개
-
수산 대사체학 연구실(Aquatic Metabolomics Lab)은 비표적 및 표적 대사체학 접근 방식을 활용하여 기후변화와 양식환경에 따른 수생 생물의 종합적인 대사체 변화를 관찰하고, 관련 대사경로와 네트워크를 밝히는 연구실이다. 이를 통해 환경 변화에 의한 수생 생물의 생체표지자(biomarker) 및 분자 표적(molecular target)을 발굴하고, 생물학적 변화를 유도하는 메커니즘을 규명할 수있는 연구과제를 수행하며, 수생 생물 유래 세포를 이용하여 대사체 분석을 포함한 다양한 in vitro/in vivo 분석을 실시함으로써 수생 환경 유해물질에 의한 독성 발현 경로를 밝히고자 한다.
지도교수님
김보연 교수
주소 (48513) 부산광역시 남구 용소로 45 부경대학교 수산과학대학 수산생명과학부 양식응용생명과학전공
이메일 boyunkim@pknu.ac.kr
전화번호 051-629-5913
홈페이지
- 연구업적
- Boyun Kim, Jewon Jung. Impact of Obesity and Lysosomal Dysfunction on Chemo-resistance in Ovarian Cancer. Biomedicines, 2024.
- Boyun Kim, Jewon Jung. Metabolomic Approaches to Identify Potential Biomarkers in KRAS-Mutant Pancreatic Cancer Cells. Biomedicines, 2024.
- Boyun Kim, Gaeun Kim, Hyun Pyo Jeon, Jewon Jung. Lipidomics analysis unravles aberrant lipid species and pathways induced by Zinc Oxide nanoparticles in kidney cells. International Journal of Molecular Sciences, 2024.
- Boyun Kim, Gaeun Kim, Heeyeon Kim, Yong Sang Song, Jewon Jung. Modulation of Cisplatin Sensitivity through TRPML1-Mediated Lysosomal Exocytosis in Ovarian Cancer Cells: A Comprehensive Metabolomic Approach. Cells, 2024.
- (*Co-first authors) Yu Jin Ahn*, Boyun Kim*, Yoon Hee Kim, Tae Young Kim, Hyeyeong Seo, Yooheon Park, Sung-Soo Park, Yejin Ahn. Enzyme-treated Zizania latifolia Ethanol Extract Improves 1 Liver-related Outcomes and Fatigability. Foods, 2024
- Juwon Lee, Youngjin Han, Soochi Kim, HyunA Jo, Wenyu Wang, Untack Cho, Se Ik Kim, Boyun Kim, Yong Sang Song. Mitochondrial fission enhances IL-6-induced metastatic potential in ovarian cancer via ERK1/2 activation. Cancer Science, 2024.
- Nari Kim, Yejin Ahn, Kayoung Ko, Boyun Kim, Kisso Han, Hyung Joo Suh, Jewon Jung, Ki-Bae Hong. Yeast Hydrolysate Inhibits Lipid Accumulation via Regulation of Lipid Accumulation-Related Genes in a Drosophila Model of High-Sugar Diet-Induced Obesity. International Journal of Molecular Sciences, 2023.
- Wook Hyun Cha, Boyun Kim, Dae-Weon Lee. Functional Analysis of Pheromone Biosynthesis Activating Neuropeptide Receptor Isoforms in Maruca vitrata. Cells, 2023.
- Boyun Kim, Gaeun Kim, Soyeon Jeon, Wan-Seob Cho, Hyun Pyo Jeon, Jewon Jung. Zinc Oxide Nanoparticles Trigger Autophagy-mediated Cell Death through Activating Lysosomal TRPML1 in Normal Kidney Cells. Toxicology Reports, 2023.
- Wenyu Wang, Untack Cho, Anna Yoo, Chae-Lim Jung, Boyun Kim, Heeyeon Kim, Juwon Lee, HyunA Jo, Youngjin Han, Myong-Hyun Song, Ja-Oh Lee, Se Ik Kim, Maria Lee, Ja-Lok Ku, Cheol Lee, Yong Sang Song. Wnt/β-Catenin Inhibition by CWP232291 as a Novel Therapeutic Strategy in Ovarian Cancer. Frontiers in Oncology, 2022.
- Boyun Kim, Victor Guaregua, Xuebo Chen, Chad Zhao, Wanyi Yeow, Nathaniel K. Berg, Holger K. Eltzschig, Xiaoyi Yuan. Characterization of a Murine Model System to Study MicroRNA-147 During Inflammatory Organ Injury. Inflammation, 2021.
- Cynthia Ju, Meng Wang, Eunyoung Tak, Boyun Kim, Christoph Emontzpohl, Yang Yang, Xiaoyi Yuan, Huban Kutay, Yafen Liang, David R. Hall, Wasim A. Dar, J. Steve Bynon, Peter Carmeliet, Kalpana Ghoshal, Holger K. Eltzschig. Hypoxia-inducible factor–1α–dependent induction of miR122 enhances hepatic ischemia tolerance. The Journal of Clinical Investigation, 2021
- Nathaniel K. Berg, Jiwen Li, Boyun Kim, Tingting Mills, Guangsheng Pei, Zhongming Zhao, Xiangyun Li, Xu Zhang, Wei Ruan, Holger K. Eltzschig, Xiaoyi Yuan. Hypoxia-inducible factor-dependent induction of myeloid-derived netrin-1 attenuates natural killer cell infiltration during endotoxin-induced lung injury. FASEB, 2021.
- Jiwen Li, Catharina Conrad, Tingting W. Mills, Nathaniel K. Berg, Boyun Kim, Wei Ruan, Jae W. Lee, Xu Zhang, Xiaoyi Yuan, Holger K. Eltzschig. PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling. Journal of Experimental Medicine, 2021.
- Boyun Kim, Yanyu Wang, Eltzschig K. Holger. Kidney Protection: Strategies for Renal Preservation. Anesthesia & Analgesia, 2020.
- Md Hafiz Udding, Boyun Kim, Untack Cho, Asfar S Azmi, Yong Sang Song. Association of ALDH1A1-NEK-2 axis in cisplatin resistance in ovarian cancer cells. Heliyon, 2020.
- In Sil Park, Boyun Kim, Youngjin Han, Hee Yang, Untack Cho, Se Ik Kim, Jong Hun Kim, Jung Han Yoon Park, Ki Won Lee, Yong Sang Song. Decursin and Decursinol Angelate Suppress Adipogenesis through Activation of β-catenin Signaling Pathway in Human Visceral Adipose-Derived Stem Cells. Nutrients, 2019.
- Youngjin Han, Boyun Kim, Untack Cho, In Sil Park, Se Ik Kim, Danny N. Dhanasekaran, Benjamin K. Tsang, Yong Sang Song. Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells. Oncogene, 2019.
- Untack Cho, Boyun Kim, Soochi Kim, Youngjin Han, Yong Sang Song. Pro-inflammatory M1 macrophage enhances metastatic potential of ovarian cancer cells through NF-κB activation. Molecular Carcinogenesis, 2018.
- Sungsik Kim, Soochi Kim, Jinhyun kim, Boyun Kim, Se Ik Kim, Min A Kim, Sunghoon Kwon, Yong Sang Song. Evaluating tumor evolution via genomic profiling of individual tumor spheroids in a malignant ascites. Scientific Reports, 2018.
- Boyun Kim, Je Won Jung, Jaeyoung Jung, Youngjin Han, Hee Seung Kim, Danny N. Dhanasekaran, Yong Sang Song. PGC1α induced by reactive oxygen species in tumor spheres and patient-derived ascites cells confers chemoresistance to ovarian cancer. Oncotarget, 2017.
- Boyun Kim, Hee Seung Kim, Soochi Kim, Guy Haegeman, Benjamin K Tsang, Danny N. Dhanasekaran, Yong Sang Song. Adipose stromal cells from visceral and subcutaneous fat facilitate migration of ovarian cancer cells via IL-6/JAK2/STAT3 pathway. Cancer Research and Treatment, 2017.
- Boyun Kim, Boram Lee, Mi-Kyung Kim, Seung Pyo Gong, Noh Hyun Park, Hyun Hoon Chung, Hee Seung Kim, Jae Hong No, Woong Yang Park, Ae Kyung Park, Jeong Mook Lim, Yong Sang Song. Gene expression profiles of human subcutaneous and visceral adipose-derived stem cells. Cell Biochemistry and Function, 2016.
- Soochi Kim, Boyun Kim, Yong Sang Song. Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer. Cancer Science, 2016.
- Soochi Kim, Hyeran Gwak, Hee Seung Kim, Boyun Kim, Danny N. Dhanasekaran, Yong Sang Song. Malignant ascites enhances migratory and invasive properties of ovarian cancer cells with membrane bound IL-6R in vitro. Oncotarget, 2016.
- Boyun Kim, Yong Sang Song. Mitochondrial dynamics altered by oxidative stress in cancer. Free Radical Research, 2016.
- Boyun Kim, Eun Ji Jung, Jung Yun Lee, Benjamin K Tsang, Jeong Mook Lim, Yong Sang Song. Curcumin induces ER stress-mediated apoptosis through selective generation of reactive oxygen species in cervical cancer cells. Molecular Carcinogenesis, 2016.
- Jeong-ah Seo, Boyun Kim, Danny N. Dhanasekaran, Benjamin K. Tsang, Yong Sang Song. Curcumin Induces apoptosis by inhibiting sacro/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells. Cancer Letters, 2016.
- Heesun Moon, Boyun Kim, HyeRan Gwak, Dong Hoon Suh, Yong Sang Song. Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2α) pathway protect ovarian cancer cells from metformin-induced apoptosis. Molecular Carcinogenesis, 2016.
- Yoon-Hee Hong, Md. Hafiz Uddin, Untek Jo, Boyun Kim, Dong Hoon Suh, Hee Seung Kim, Jiyoung Song, Yong Sang Song. ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis. Frontiers in Oncology, 2015.
- Jung-Yun Lee, Jung-Ki Yoon, Boyun Kim, Soochi Kim, Min A Kim, Hyeonseop Lim, Duhee Bang, Yong Sang Song. Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing. BMC Cancer, 2015.
- Seung Pyo Gong, Boyun Kim, Hyo Sook Kwon, Woo Sub Yang, Jae-Wook Jeong, Jiyeon Ahn, Jeong Mook Lim. The co-injection of somatic cells with embryonic stem cells affects teratoma formation and the properties of teratoma-derived stem cell-like cells. PLoS One, 2014.
- Dong Hoon Suh, Hee Seung Kim, Boyun Kim, Yong Sang Song. Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: A therapeutic implication. Biochemical Pharmacology, 2014.
- Md. Hafiz Uddin, Boyun Kim, Dong Hoon Suh, Yong Sang Song. Anticancer strategy targeting mitochondrial biogenesis in ovarian cancer. Journal of Cancer Science and Therapy, 2014.
- Mi-Kyung Kim, Dong Hoon Suh, Boyun Kim, Yong Sang Song. Cellular stress responses and cancer: new mechanistics insights on anticancer effect by phytochemicals. Phytochemistry Reviews, 2014.
- Doori Park, Je Won Jung, Mi Ok Lee, Si Young Lee, Boyun Kim, Hye Jun Jin, Jiyoung Kim, Young-Joon Ahn, Ki Won Lee, Yong Sang Song, Seunghun Hong, James E. Womack, Hyung Wook Kwon. Functional characterization of naturally occurring melittin peptide isoforms in two honey bee species, Apis mellifera and Apis cerana. Peptides, 2014.
- 연구실인원
-
재학생, 이름으로 구성된 연구실인원표입니다. 이름 과정 정예진
대학원생(석사과정)
박태은
학부생